A new pre-clinical study – co-lead by UCLA researchers - could prevent patients treated for cancer or osteoporosis from experiencing jawbone damage as a result of oral surgery. Bisphosphonates are currently used to treat patients who have bone cancer or osteoporosis. These drugs bind to the skeleton and prevent a loss in bone density and remain bound to bones for months or even years after initial treatment.
For the study – published in Bone Science Digest - researchers from UCLA collaborating with colleagues at USC were able to remove the bisphosphonate drugs from the jawbone by injecting another kind of bisphosphonate compound that is inert and doesn’t have pharmacological effect. This technique displaced the bisphosphonate drug bound to the jawbone’s surface. The potential advantage of this technique in a clinical setting would allow the bisphosphonate drugs to remain bound to the rest of the skeleton and continue to prevent bone loss while being displaced from the jawbone and clearing the way for oral surgery.
In some cases, cancer patients who receive high doses of a bisphosphonate drug during treatment experience jaw damage as a result of routine oral surgery. The presence of the bisphosphonates bound to the jawbone can cause painful and chronic inflammation and infection as a side effect of a common oral procedure such as tooth removal. This can lead to the loss of jawbone tissue.
There is no known way to either treat or prevent this potentially deadly side effect from occurring. “When being treated for cancer, the infusion of the high dose bisphosphonate drug is an important tool to control bone pain and osteolysis in patients with cancers,” says Dr. Ichiro Nishimura, a professor of prosthodontics with the UCLA School of Dentistry and a member of the UCLA Jonsson Comprehensive Cancer Center. “These are cancers that originate in bone marrow, such as multiple myeloma, or that have metastasized to the skeleton, such as from breast and prostate cancers. The presence of this bisphosphonate represents a significant risk particularly following needed routine dental surgery.”